Cargando…

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

BACKGROUND: TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer’s disease (AD). Soluble TREM2 (sTREM2) resulting from shedding of the TREM2 ectodomain can be detected...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Schlepckow, Kai, Caballero, Miguel Ángel Araque, Franzmeier, Nicolai, Capell, Anja, Fellerer, Katrin, Nuscher, Brigitte, Eren, Erden, Levin, Johannes, Deming, Yuetiva, Piccio, Laura, Karch, Celeste M., Cruchaga, Carlos, Shaw, Leslie M., Trojanowski, John Q., Weiner, Michael, Ewers, Michael, Haass, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327425/ https://www.ncbi.nlm.nih.gov/pubmed/30630532 http://dx.doi.org/10.1186/s13024-018-0301-5

Ejemplares similares

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
por: Suárez‐Calvet, Marc, et al.
Publicado: (2018)

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
por: Ewers, Michael, et al.
Publicado: (2020)

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
por: Franzmeier, Nicolai, et al.
Publicado: (2020)

sTREM2 is associated with amyloid‐related p‐tau increases and glucose hypermetabolism in Alzheimer's disease
por: Biel, Davina, et al.
Publicado: (2023)

Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study
por: Morenas-Rodríguez, Estrella, et al.
Publicado: (2022)

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
por: Schlepckow, Kai, et al.
Publicado: (2017)

The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
por: Gispert, Juan Domingo, et al.
Publicado: (2016)

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
por: Suárez‐Calvet, Marc, et al.
Publicado: (2016)

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
por: Xiang, Xianyuan, et al.
Publicado: (2016)

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease
por: Hok-A-Hin, Yanaika S., et al.
Publicado: (2023)

sTREM-1 is a specific biomarker of TREM-1 pathway activation
por: Jolly, Lucie, et al.
Publicado: (2021)

The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?
por: Ferri, Evelyn, et al.
Publicado: (2021)

Leishmania infantum Induces the Release of sTREM-1 in Visceral Leishmaniasis
por: Bomfim, Lays G. S., et al.
Publicado: (2017)

Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis
por: Jiang, Jiahui, et al.
Publicado: (2020)

Neuroinflammation Is Associated with GFAP and sTREM2 Levels in Multiple Sclerosis
por: Azzolini, Federica, et al.
Publicado: (2022)

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
por: Schlepckow, Kai, et al.
Publicado: (2020)

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
por: Götzl, Julia K, et al.
Publicado: (2019)

γ‐Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
por: Steiner, Andrea, et al.
Publicado: (2020)

sTREM-1 as a Prognostic Marker of Postoperative Complications in Cardiac Surgery
por: Golovkin, A. S., et al.
Publicado: (2012)

Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis
por: Aksaray, Sebahat, et al.
Publicado: (2017)

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals
por: Falcon, Carles, et al.
Publicado: (2019)

Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models
por: Kleinberger, Gernot, et al.
Publicado: (2012)

Association of decreased serum sTREM-1 level with the severity of coronary artery disease: Inhibitory effect of sTREM-1 on TNF-α- and oxLDL-induced inflammatory reactions in endothelial cells
por: Dai, Daopeng, et al.
Publicado: (2016)

CSF sTREM2: marking the tipping point between preclinical AD and dementia?
por: Schindler, Suzanne E, et al.
Publicado: (2016)

Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children
por: Smok, Beata, et al.
Publicado: (2020)

Dynamic changes of CSF sTREM2 in preclinical Alzheimer’s disease: the CABLE study
por: Ma, Ling-Zhi, et al.
Publicado: (2020)

Plasma sTREM2: a potential marker of cerebrovascular injury in neurodegenerative disorders
por: Rodriguez-Vieitez, Elena, et al.
Publicado: (2021)

sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients
por: Bezerra-Santos, Márcio, et al.
Publicado: (2023)

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
por: Xiang, Xianyuan, et al.
Publicado: (2018)

African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants
por: Schindler, Suzanne E., et al.
Publicado: (2021)

Soluble TREM2: Innocent bystander or active player in neurological diseases?
por: Filipello, Fabia, et al.
Publicado: (2022)

Urine sTREM-1 assessment in diagnosing sepsis and sepsis-related acute kidney injury
por: Derive, Marc, et al.
Publicado: (2011)

Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis
por: Su, Longxiang, et al.
Publicado: (2016)

Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification
por: Knapskog, Anne-Brita, et al.
Publicado: (2020)

Evaluation of sTREM1 and suPAR Biomarkers as Diagnostic and Prognostic Predictors in Sepsis Patients
por: Nasr El-Din, Asmaa, et al.
Publicado: (2021)

CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study
por: Dong, Ming-Hao, et al.
Publicado: (2022)

sTREM2 is a plasma biomarker for human NASH and promotes hepatocyte lipid accumulation
por: Kothari, Vishal, et al.
Publicado: (2023)

sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology
por: Nabizadeh, Fardin
Publicado: (2023)

Validation of sTREM-1 and IL-6 based algorithms for outcome prediction of COVID-19
por: Van Singer, Mathias, et al.
Publicado: (2023)

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
por: Reifschneider, Anika, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1at1pcq5o418v7cao6u06s0kri