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miR-21 enhances the protective effect of loperamide on rat cardiomyocytes against hypoxia/reoxygenation, reactive oxygen species production and apoptosis via regulating Akap8 and Bard1 expression

Effective therapies to reduce ischemia/reperfusion and hypoxia/reoxygenation injury are currently lacking. Furthermore, the effects of loperamide and microRNA (miR)-21 on hypoxia/reoxygenation injury of cardiomyocytes have remained to be elucidated. Therefore, the present study aimed to investigate...

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Detalles Bibliográficos
Autores principales: Shen, Hong, Yao, Zhifeng, Zhao, Weipeng, Zhang, Yaping, Yao, Chenling, Tong, Chaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327625/
https://www.ncbi.nlm.nih.gov/pubmed/30680008
http://dx.doi.org/10.3892/etm.2018.7047