Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit compounds. Testing the screened hit compounds has led to several novel submicromolar inhibitors. Especially for compounds LVS-019 with cyanopyridine...

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Detalles Bibliográficos
Autores principales: Xu, Xi, Ren, Jie, Ma, Yinghe, Liu, Hongting, Rong, Quanjin, Feng, Yifan, Wang, Yameng, Cheng, Yu, Ge, Ruijia, Li, Zhiyu, Bian, Jinlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327983/
https://www.ncbi.nlm.nih.gov/pubmed/30734612
http://dx.doi.org/10.1080/14756366.2018.1480614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327983/
https://www.ncbi.nlm.nih.gov/pubmed/30734612
http://dx.doi.org/10.1080/14756366.2018.1480614

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