(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

Using histamine as lead molecule, a library of (hetero)aryl substituted thiazol-2,4-yl derivatives incorporating pyridine as proton shuttling moiety were obtained and investigated as activators of human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I, II, VII and XIV. Some derivatives displayed good...

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Detalles Bibliográficos
Autores principales: Rami, Marouan, Winum, Jean-Yves, Supuran, Claudiu T., Melnyk, Patricia, Yous, Saïd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327990/
https://www.ncbi.nlm.nih.gov/pubmed/30734616
http://dx.doi.org/10.1080/14756366.2018.1543292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327990/
https://www.ncbi.nlm.nih.gov/pubmed/30734616
http://dx.doi.org/10.1080/14756366.2018.1543292

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