Cargando…

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

Using histamine as lead molecule, a library of (hetero)aryl substituted thiazol-2,4-yl derivatives incorporating pyridine as proton shuttling moiety were obtained and investigated as activators of human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I, II, VII and XIV. Some derivatives displayed good...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rami, Marouan, Winum, Jean-Yves, Supuran, Claudiu T., Melnyk, Patricia, Yous, Saïd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327990/ https://www.ncbi.nlm.nih.gov/pubmed/30734616 http://dx.doi.org/10.1080/14756366.2018.1543292

Ejemplares similares

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
por: Abdoli, Morteza, et al.
Publicado: (2017)

Multivalent Carbonic Anhydrases Inhibitors †
por: Carta, Fabrizio, et al.
Publicado: (2019)

2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2023)

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
por: McDonald, Paul C., et al.
Publicado: (2012)

Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives
por: Akocak, Suleyman, et al.
Publicado: (2019)

4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2022)

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators
por: Angeli, Andrea, et al.
Publicado: (2017)

An Electron-Transporting Thiazole-Based Polymer Synthesized Through Direct (Hetero)Arylation Polymerization
por: Chávez, Patricia, et al.
Publicado: (2018)

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases
por: Distinto, Simona, et al.
Publicado: (2019)

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies
por: Aspatwar, Ashok, et al.
Publicado: (2018)

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles
por: Nocentini, Alessio, et al.
Publicado: (2017)

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2018)

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors
por: Akocak, Suleyman, et al.
Publicado: (2018)

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators
por: Nocentini, Alessio, et al.
Publicado: (2020)

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators
por: Akocak, Suleyman, et al.
Publicado: (2017)

Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage
por: Monti, Daria M., et al.
Publicado: (2016)

Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII
por: Angeli, Andrea, et al.
Publicado: (2017)

Carbonic Anhydrases and Metabolism
por: Supuran, Claudiu T.
Publicado: (2018)

Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII
por: Fiorentino, Francesco, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors
por: Manasa, Kesari Lakshmi, et al.
Publicado: (2020)

Photochemical (Hetero-)Arylation of Aryl Sulfonium Salts
por: Zhao, Yue, et al.
Publicado: (2021)

Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors
por: Pustenko, Aleksandrs, et al.
Publicado: (2019)

A palladium-catalyzed synthesis of (hetero)aryl-substituted imidazoles from aryl halides, imines and carbon monoxide
por: Tjutrins, Jevgenijs, et al.
Publicado: (2017)

An Overview of the Bacterial Carbonic Anhydrases
por: Supuran, Claudiu T., et al.
Publicado: (2017)

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
por: Melis, Claudia, et al.
Publicado: (2016)

The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV
por: Parkkila, Seppo, et al.
Publicado: (2002)

A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity
por: Sarnella, Annachiara, et al.
Publicado: (2020)

Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors
por: Thacker, Pavitra S., et al.
Publicado: (2019)

Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors
por: Supuran, Claudiu T.
Publicado: (2017)

Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold
por: Romagnoli, Romeo, et al.
Publicado: (2023)

Acipimox inhibits human carbonic anhydrases
por: Mori, Mattia, et al.
Publicado: (2022)

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII
por: Buran, Kerem, et al.
Publicado: (2019)

Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides
por: Angeli, Andrea, et al.
Publicado: (2023)

Coumarin carbonic anhydrase inhibitors from natural sources
por: Supuran, Claudiu T.
Publicado: (2020)

Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors
por: Supuran, Claudiu T
Publicado: (2020)

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities
por: Supuran, Claudiu T.
Publicado: (2022)

Carbonic Anhydrase Inhibitors from Marine Natural Products
por: Supuran, Claudiu T.
Publicado: (2022)

Polyamines and α-Carbonic Anhydrases
por: Scozzafava, Andrea, et al.
Publicado: (2016)

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
por: Nocentini, Alessio, et al.
Publicado: (2021)

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
por: Gumus, Arzu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jor4r4bok01alkdpmibvaa7cc2