The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1

Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kin...

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Detalles Bibliográficos
Autores principales: Xu, Xinyuan, Chen, Yingyi, Fu, Qiang, Ni, Duan, Zhang, Jian, Li, Xiaolong, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327997/
https://www.ncbi.nlm.nih.gov/pubmed/30734603
http://dx.doi.org/10.1080/14756366.2018.1553167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327997/
https://www.ncbi.nlm.nih.gov/pubmed/30734603
http://dx.doi.org/10.1080/14756366.2018.1553167

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