Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH) that binds reversi...

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Detalles Bibliográficos
Autores principales: Misko, Tessianna A., Liu, Yi-Ting, Harris, Michael E., Oleinick, Nancy L., Pink, John, Lee, Hsueh-Yun, Dealwis, Chris G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328008/
https://www.ncbi.nlm.nih.gov/pubmed/30734609
http://dx.doi.org/10.1080/14756366.2018.1545226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328008/
https://www.ncbi.nlm.nih.gov/pubmed/30734609
http://dx.doi.org/10.1080/14756366.2018.1545226

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