Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

Enterohemorrhagic Escherichia coli (EHEC) colonize intestinal epithelium by generating characteristic attaching and effacing (AE) lesions. They are lysogenized by prophage that encode Shiga toxin 2 (Stx2), which is responsible for severe clinical manifestations. As a lysogen, prophage genes leading...

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Detalles Bibliográficos
Autores principales: Balasubramanian, Sowmya, Osburne, Marcia S., BrinJones, Haley, Tai, Albert K., Leong, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328086/
https://www.ncbi.nlm.nih.gov/pubmed/30629725
http://dx.doi.org/10.1371/journal.ppat.1007494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328086/
https://www.ncbi.nlm.nih.gov/pubmed/30629725
http://dx.doi.org/10.1371/journal.ppat.1007494

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