ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

The cell cycle is under circadian regulation. Oncogenes can dysregulate circadian-regulated genes to disrupt the cell cycle, promoting tumor cell proliferation. As a regulator of G2/M arrest in response to DNA damage, the circadian gene Timeless Circadian Clock (TIMELESS) coordinates this connection...

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Detalles Bibliográficos
Autores principales: Neilsen, Beth K., Frodyma, Danielle E., McCall, Jamie L., Fisher, Kurt W., Lewis, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328106/
https://www.ncbi.nlm.nih.gov/pubmed/30629587
http://dx.doi.org/10.1371/journal.pone.0209224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328106/
https://www.ncbi.nlm.nih.gov/pubmed/30629587
http://dx.doi.org/10.1371/journal.pone.0209224

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