Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DN...

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Detalles Bibliográficos
Autores principales: Ramanagoudr-Bhojappa, Ramanagouda, Carrington, Blake, Ramaswami, Mukundhan, Bishop, Kevin, Robbins, Gabrielle M., Jones, MaryPat, Harper, Ursula, Frederickson, Stephen C., Kimble, Danielle C., Sood, Raman, Chandrasekharappa, Settara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328202/
https://www.ncbi.nlm.nih.gov/pubmed/30540754
http://dx.doi.org/10.1371/journal.pgen.1007821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328202/
https://www.ncbi.nlm.nih.gov/pubmed/30540754
http://dx.doi.org/10.1371/journal.pgen.1007821

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