Cdk12 regulates DNA repair genes by suppressing intronic polyadenylation

Mutations that attenuate homologous recombination (HR) repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as “BRCAness.”(1) BRCAness tumors arise from loss-of-function mutations in 22 genes.(1) Of these genes, all but one (Cd...

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Detalles Bibliográficos
Autores principales: Dubbury, Sara J., Boutz, Paul L., Sharp, Phillip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328294/
https://www.ncbi.nlm.nih.gov/pubmed/30487607
http://dx.doi.org/10.1038/s41586-018-0758-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328294/
https://www.ncbi.nlm.nih.gov/pubmed/30487607
http://dx.doi.org/10.1038/s41586-018-0758-y

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