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Cdk12 regulates DNA repair genes by suppressing intronic polyadenylation
Mutations that attenuate homologous recombination (HR) repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as “BRCAness.”(1) BRCAness tumors arise from loss-of-function mutations in 22 genes.(1) Of these genes, all but one (Cd...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328294/ https://www.ncbi.nlm.nih.gov/pubmed/30487607 http://dx.doi.org/10.1038/s41586-018-0758-y |