Cargando…

Exposure of Barrett’s and esophageal adenocarcinoma cells to Bile acids activates EGFR-STAT3 signaling axis via induction of APE1

The development of Barret’s esophagus (BE) and its progression to esophageal adenocarcinoma (EAC) is highly linked to exposure to acidic bile salts due to chronic gastroesophageal reflux disease (GERD). In this study, we investigated the role of Apurinic/apyrimidinic endonuclease 1 /redox effector f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhat, Ajaz A., Lu, Heng, Soutto, Mohammed, Capobianco, Anthony, Rai, Priyamvada, Zaika, Alexander, El-Rifai, Wael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328352/ https://www.ncbi.nlm.nih.gov/pubmed/29991802 http://dx.doi.org/10.1038/s41388-018-0388-8

Ejemplares similares

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells
por: Sriramajayam, Kannappan, et al.
Publicado: (2021)

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
por: Ballout, Farah, et al.
Publicado: (2022)

APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts
por: Hong, Jun, et al.
Publicado: (2016)

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis
por: Peng, Dun-Fa, et al.
Publicado: (2014)

NF-kB-dependent activation of STAT3 by H. pylori is suppressed by TFF1
por: Soutto, Mohammed, et al.
Publicado: (2021)

The antioxidant response in Barrett's tumorigenesis: A double-edged sword
por: Peng, Dunfa, et al.
Publicado: (2021)

Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
por: Zhu, Shoumin, et al.
Publicado: (2019)

Proinflammatory Cytokines and Bile Acids Upregulate ΔNp73 Protein, an Inhibitor of p53 and p73 Tumor Suppressors
por: Zaika, Elena, et al.
Publicado: (2013)

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
por: Soutto, Mohammed, et al.
Publicado: (2019)

Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
por: Zhou, Zhangjian, et al.
Publicado: (2019)

COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells
por: Jiangang, Shen, et al.
Publicado: (2022)

TFF1 activates p53 through down-regulation of miR-504 in gastric cancer
por: Soutto, Mohammed, et al.
Publicado: (2014)

Pediatric Patient With Concurrent Eosinophilic Esophagitis, Erosive Reflux Esophagitis, and Barrett's Esophagus
por: Sharma, Ishna, et al.
Publicado: (2020)

PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer
por: Wang, Sen, et al.
Publicado: (2019)

Regulation of Desmocollin3 Expression by Promoter Hypermethylation is Associated with Advanced Esophageal Adenocarcinomas
por: Wang, Qinggang, et al.
Publicado: (2014)

Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma
por: Lv, Jing, et al.
Publicado: (2019)

Chemoprevention in Barrett’s esophagus and esophageal adenocarcinoma
por: Alkhayyat, Motasem, et al.
Publicado: (2021)

Recurring Translocations in Barrett’s Esophageal Adenocarcinoma
por: Bajpai, Manisha, et al.
Publicado: (2021)

Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis
por: Palrasu, Manikandan, et al.
Publicado: (2021)

Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells
por: Li, Dan, et al.
Publicado: (2016)

CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis
por: Zhu, Shoumin, et al.
Publicado: (2023)

Esophageal microbiome signature in patients with Barrett’s esophagus and esophageal adenocarcinoma
por: Lopetuso, Loris Riccardo, et al.
Publicado: (2020)

Activation of NADPH oxidases leads to DNA damage in esophageal cells
por: Bhardwaj, Vikas, et al.
Publicado: (2017)

Biomarkers in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma
por: Williams, L.J., et al.
Publicado: (2006)

Photodynamic Therapy for Barrett's Esophagus and Esophageal Carcinoma
por: Qumseya, Bashar J., et al.
Publicado: (2013)

Origin of Barrett’s Epithelium: Esophageal Submucosal Glands
por: Garman, Katherine S.
Publicado: (2017)

Immune determinants of Barrett’s progression to esophageal adenocarcinoma
por: Lagisetty, Kiran H., et al.
Publicado: (2021)

Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma
por: Islam, Md Obaidul, et al.
Publicado: (2023)

Usefulness of the Japan Esophageal Society Classification of Barrett's Esophagus for Diagnosing the Lateral Extent of Superficial Short-Segment Barrett's Esophageal Cancer
por: Suzuki, Yugo, et al.
Publicado: (2022)

Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells
por: Vangamudi, Bhavatarini, et al.
Publicado: (2011)

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus
por: Chen, Lei, et al.
Publicado: (2023)

Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure
por: Hao, Ying, et al.
Publicado: (2007)

From APE to APE-100: present and future of the APE project
por: Bacilieri, P, et al.
Publicado: (1988)

Barrett's Esophageal Adenocarcinoma Involving a White Globe Appearance within the Long-Segment Barrett's Esophagus
por: Kubota, Yo, et al.
Publicado: (2020)

Urinary metabolomic signature of esophageal cancer and Barrett’s esophagus
por: Davis, Vanessa W, et al.
Publicado: (2012)

Progression of Barrett’s esophagus toward esophageal adenocarcinoma: an overview
por: Schoofs, Nele, et al.
Publicado: (2017)

Advances in the management of Barrett’s esophagus and early esophageal adenocarcinoma
por: Singh, Ajaypal, et al.
Publicado: (2015)

Barrett’s esophagus and esophageal cancer: Links to microbes and the microbiome
por: Ajayi, Teminioluwa A., et al.
Publicado: (2018)

Barrett’s Epithelium to Esophageal Adenocarcinoma: Is There a “Point of No Return”?
por: Panda, Anshuman, et al.
Publicado: (2021)

Signaling Pathways in the Pathogenesis of Barrett’s Esophagus and Esophageal Adenocarcinoma
por: Maslenkina, Ksenia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h2am82e25toefv5ln9u7sekhas