CRISPR/Cas9-Mediated Chicken TBK1 Gene Knockout and Its Essential Role in STING-Mediated IFN-β Induction in Chicken Cells

TANK-binding kinase 1 (TBK1) is involved in innate immunity, prompting transcriptional induction of type I interferons in response to pathogenic infection. Many studies have focused on mammals but the function of TBK1 in chickens remains poorly defined. CRISPR/Cas9 system has made gene-knockout easy...

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Detalles Bibliográficos
Autores principales: Cheng, Yuqiang, Lun, Minxiang, Liu, Yunxia, Wang, Hengan, Yan, Yaxian, Sun, Jianhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328437/
https://www.ncbi.nlm.nih.gov/pubmed/30662438
http://dx.doi.org/10.3389/fimmu.2018.03010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328437/
https://www.ncbi.nlm.nih.gov/pubmed/30662438
http://dx.doi.org/10.3389/fimmu.2018.03010

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