Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules that recruit an E3 ubiquitin ligase to a given substrate protein resulting in its targeted degradation. Many potent PROTACs with specificity for dissimilar targets have been developed; however, the factors governing degradati...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Blake E., Wang, Stephen L., Jaime-Figueroa, Saul, Harbin, Alicia, Wang, Jing, Hamman, Brian D., Crews, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328587/
https://www.ncbi.nlm.nih.gov/pubmed/30631068
http://dx.doi.org/10.1038/s41467-018-08027-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328587/
https://www.ncbi.nlm.nih.gov/pubmed/30631068
http://dx.doi.org/10.1038/s41467-018-08027-7

Ejemplares similares