Shifts in the selectivity filter dynamics cause modal gating in K(+) channels

Spontaneous activity shifts at constant experimental conditions represent a widespread regulatory mechanism in ion channels. The molecular origins of these modal gating shifts are poorly understood. In the K(+) channel KcsA, a multitude of fast activity shifts that emulate the native modal gating be...

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Detalles Bibliográficos
Autores principales: Jekhmane, Shehrazade, Medeiros-Silva, João, Li, Jing, Kümmerer, Felix, Müller-Hermes, Christoph, Baldus, Marc, Roux, Benoît, Weingarth, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328603/
https://www.ncbi.nlm.nih.gov/pubmed/30631074
http://dx.doi.org/10.1038/s41467-018-07973-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328603/
https://www.ncbi.nlm.nih.gov/pubmed/30631074
http://dx.doi.org/10.1038/s41467-018-07973-6

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