Cargando…

Critical Appraisal of Programmed Death Ligand 1 Reflex Diagnostic Testing: Current Standards and Future Opportunities

INTRODUCTION: Patient suitability to anti–programmed death ligand 1 (PD-L1) immune checkpoint inhibition is key to the treatment of NSCLC. We present, applied to PD-L1 testing: a comprehensive cross-validation of two immunohistochemistry (IHC) clones; our descriptive experience in diagnostic reflex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Humphries, Matthew P., McQuaid, Stephen, Craig, Stephanie G., Bingham, Victoria, Maxwell, Perry, Maurya, Manisha, McLean, Fiona, Sampson, James, Higgins, Patricia, Greene, Christine, James, Jacqueline, Salto-Tellez, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328626/ https://www.ncbi.nlm.nih.gov/pubmed/30296485 http://dx.doi.org/10.1016/j.jtho.2018.09.025

Ejemplares similares

Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization
por: Humphries, Matthew P., et al.
Publicado: (2020)

PD-L1 Multiplex and Quantitative Image Analysis for Molecular Diagnostics
por: Abdullahi Sidi, Fatima, et al.
Publicado: (2020)

Exploring the immune microenvironment in small bowel adenocarcinoma using digital image analysis
por: Sidi, Fatima Abdullahi, et al.
Publicado: (2023)

RNAscope in situ hybridization confirms mRNA integrity in formalin-fixed, paraffin-embedded cancer tissue samples
por: Bingham, Victoria, et al.
Publicado: (2017)

Technical note on the exploration of COVID-19 in autopsy material
por: Humphries, Matthew Phillip, et al.
Publicado: (2023)

The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation
por: Humphries, Matthew P., et al.
Publicado: (2020)

Quantification of HER2 heterogeneity in breast cancer–implications for identification of sub-dominant clones for personalised treatment
por: Buckley, Niamh E., et al.
Publicado: (2016)

Sex hormone receptor expression and survival in esophageal adenocarcinoma: a prospective cohort study
por: McMenamin, Úna C., et al.
Publicado: (2018)

Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
por: McCain, Stephen, et al.
Publicado: (2018)

A gene signature associated with PTEN activation defines good prognosis intermediate risk prostate cancer cases
por: Ong, Chee W, et al.
Publicado: (2018)

Orthogonal MET analysis in a population‐representative stage II–III colon cancer cohort: prognostic and potential therapeutic implications
por: Craig, Stephanie G., et al.
Publicado: (2021)

Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention
por: Buckley, Niamh, et al.
Publicado: (2015)

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies
por: Alvi, Muhammad A, et al.
Publicado: (2017)

Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer
por: Alderdice, Matthew, et al.
Publicado: (2021)

QuPath: The global impact of an open source digital pathology system
por: Humphries, M.P., et al.
Publicado: (2021)

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study
por: McCain, R. Stephen, et al.
Publicado: (2019)

Observations on the transcriptional activity of the glutathione S-transferase pi gene in human haematological malignancies and in the peripheral leucocytes of cancer patients under chemotherapy.
por: McQuaid, S., et al.
Publicado: (1989)

Context-Dependent Diversity-Effects of Seaweed Consumption on Coral Reefs in Kenya
por: Humphries, Austin T., et al.
Publicado: (2015)

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility
por: Alvi, Muhammad A., et al.
Publicado: (2015)

Rosetting revisited: a critical look at the evidence for host erythrocyte receptors in Plasmodium falciparum rosetting
por: McQuaid, Fiona, et al.
Publicado: (2020)

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer
por: Humphries, Matthew P., et al.
Publicado: (2018)

Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer
por: Elkashif, Ahmed, et al.
Publicado: (2020)

Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer
por: Southwood, Mark, et al.
Publicado: (2019)

The clinical and molecular significance associated with STING signaling in breast cancer
por: Parkes, Eileen E., et al.
Publicado: (2021)

General Roadmap and Core Steps for the Development of AI Tools in Digital Pathology
por: Makhlouf, Yasmine, et al.
Publicado: (2022)

Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption
por: Geaney, Alice, et al.
Publicado: (2023)

Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study
por: Gray, Ronan T, et al.
Publicado: (2017)

Git in Practice
por: McQuaid, Mike
Publicado: (2014)

EXPLORING HEALTHCARE WORKERS' GERIATRIC EDUCATION AND SUBSEQUENT COMMUNICATION WITH OLDER ADULTS
por: McQuaid, Tina
Publicado: (2022)

Tissue-based next generation sequencing: application in a universal healthcare system
por: Hynes, Seán O, et al.
Publicado: (2017)

Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8 (+) T cell infiltrate
por: Porter, Ross J, et al.
Publicado: (2021)

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach
por: Craig, Stephanie G., et al.
Publicado: (2019)

Transdiagnostic biomarker approaches to mental health disorders: Consideration of symptom complexity, comorbidity and context
por: McQuaid, Robyn J.
Publicado: (2021)

Pin1 plays a key role in the response to treatment and clinical outcome in triple negative breast cancer
por: Knowlson, Catherine, et al.
Publicado: (2020)

Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
por: Craig, Stephanie G., et al.
Publicado: (2020)

A Means of Assessing Deep Learning-Based Detection of ICOS Protein Expression in Colon Cancer
por: Sarker, Md Mostafa Kamal, et al.
Publicado: (2021)

Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study
por: Gray, Ronan T, et al.
Publicado: (2017)

Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival
por: Porter, Ross J., et al.
Publicado: (2023)

The diversity of ice algal communities on the Greenland Ice Sheet as revealed by oligotyping
por: Lutz, Stefanie, et al.
Publicado: (2018)

Field Measurements Indicate Unexpected, Serious Underestimation of Mussel Heart Rates and Thermal Tolerance by Laboratory Studies
por: Tagliarolo, Morgana, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hph5el5psv9pmgu9rto6r4ajq1