Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease

Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal’s life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington’s disease (HD). To date, however, there is little direct experimental evid...

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Detalles Bibliográficos
Autores principales: Morton, A. J., Skillings, E. A., Wood, N. I., Zheng, Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328633/
https://www.ncbi.nlm.nih.gov/pubmed/30631090
http://dx.doi.org/10.1038/s41598-018-37102-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328633/
https://www.ncbi.nlm.nih.gov/pubmed/30631090
http://dx.doi.org/10.1038/s41598-018-37102-8

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