MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity

The autoimmune-mediated beta-cell death in type 1 diabetes (T1DM) is associated with local inflammation (insulitis). We examined the role of MCPIP1 (monocyte chemotactic protein–induced protein 1), a novel cytokine-induced antiinflammatory protein, in this process. Basal MCPIP1 expression was lower...

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Detalles Bibliográficos
Autores principales: Tyka, Karolina, Jörns, Anne, Turatsinze, Jean-Valery, Eizirik, Decio L., Lenzen, Sigurd, Gurgul-Convey, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328635/
https://www.ncbi.nlm.nih.gov/pubmed/30631045
http://dx.doi.org/10.1038/s41419-018-1268-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328635/
https://www.ncbi.nlm.nih.gov/pubmed/30631045
http://dx.doi.org/10.1038/s41419-018-1268-4

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