Cargando…
MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
The autoimmune-mediated beta-cell death in type 1 diabetes (T1DM) is associated with local inflammation (insulitis). We examined the role of MCPIP1 (monocyte chemotactic protein–induced protein 1), a novel cytokine-induced antiinflammatory protein, in this process. Basal MCPIP1 expression was lower...
Autores principales: | Tyka, Karolina, Jörns, Anne, Turatsinze, Jean-Valery, Eizirik, Decio L., Lenzen, Sigurd, Gurgul-Convey, Ewa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328635/ https://www.ncbi.nlm.nih.gov/pubmed/30631045 http://dx.doi.org/10.1038/s41419-018-1268-4 |
Ejemplares similares
-
To Be or Not to Be: The Divergent Action and Metabolism of Sphingosine-1 Phosphate in Pancreatic Beta-Cells in Response to Cytokines and Fatty Acids
por: Gurgul-Convey, Ewa
Publicado: (2022) -
Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
por: Tang, Yadi, et al.
Publicado: (2021) -
Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells
por: Gurgul-Convey, Ewa
Publicado: (2020) -
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
por: Brozzi, Flora, et al.
Publicado: (2016) -
Nova1 is a master regulator of alternative splicing in pancreatic beta cells
por: Villate, Olatz, et al.
Publicado: (2014)