Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic aggregation process. Here we identified and characterized cytotoxic oligomeric intermediates populated during transthyretin (TTR) aggregation process. Unde...

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Detalles Bibliográficos
Autores principales: Dasari, Anvesh K. R., Hughes, Robert M., Wi, Sungsool, Hung, Ivan, Gan, Zhehong, Kelly, Jeffrey W., Lim, Kwang Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328637/
https://www.ncbi.nlm.nih.gov/pubmed/30631096
http://dx.doi.org/10.1038/s41598-018-37230-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328637/
https://www.ncbi.nlm.nih.gov/pubmed/30631096
http://dx.doi.org/10.1038/s41598-018-37230-1

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