Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception

Aggressive breast cancer subtypes utilize system x(c)(−), a membrane antiporter, to import cystine for glutathione synthesis and maintenance of redox homeostasis, in turn releasing glutamate as a metabolic pro-nociceptive by-product. Metastatic breast cancers establish themselves at distal sites inc...

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Detalles Bibliográficos
Autores principales: Linher-Melville, Katja, Sharma, Manu, Nakhla, Peter, Kum, Elena, Ungard, Robert, Park, Ji, Rosa, David, Gunning, Patrick, Singh, Gurmit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329039/
https://www.ncbi.nlm.nih.gov/pubmed/30799695
http://dx.doi.org/10.1177/1744806918823477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329039/
https://www.ncbi.nlm.nih.gov/pubmed/30799695
http://dx.doi.org/10.1177/1744806918823477

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