Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers

Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding sites. While sometimes interpreted as functional dri...

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Detalles Bibliográficos
Autores principales: Elliott, Kerryn, Boström, Martin, Filges, Stefan, Lindberg, Markus, Van den Eynden, Jimmy, Ståhlberg, Anders, Clausen, Anders R., Larsson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329521/
https://www.ncbi.nlm.nih.gov/pubmed/30586386
http://dx.doi.org/10.1371/journal.pgen.1007849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329521/
https://www.ncbi.nlm.nih.gov/pubmed/30586386
http://dx.doi.org/10.1371/journal.pgen.1007849

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