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Statistical investigations of protein residue direct couplings

Protein Direct Coupling Analysis (DCA), which predicts residue-residue contacts based on covarying positions within a multiple sequence alignment, has been remarkably effective. This suggests that there is more to learn from sequence correlations than is generally assumed, and calls for deeper inves...

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Detalles Bibliográficos
Autores principales: Neuwald, Andrew F., Altschul, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329532/
https://www.ncbi.nlm.nih.gov/pubmed/30596639
http://dx.doi.org/10.1371/journal.pcbi.1006237