CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy

Agonist antibodies (Ab) directed against costimulatory molecules on the surface of antigen-primed T cells are in various stages of pre-clinical and clinical trials, albeit with limited therapeutic benefit as single agents. The underlying mechanisms of action remain incompletely understood. Here, we...

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Detalles Bibliográficos
Autores principales: Chen, Siqi, Fan, Jie, Zhang, Minghui, Qin, Lei, Dominguez, Donye, Long, Alan, Wang, Gaoxiang, Ma, Renqiang, Li, Huabin, Zhang, Yi, Fang, Deyu, Sosman, Jeffrey, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329764/
https://www.ncbi.nlm.nih.gov/pubmed/30635578
http://dx.doi.org/10.1038/s41467-018-08123-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329764/
https://www.ncbi.nlm.nih.gov/pubmed/30635578
http://dx.doi.org/10.1038/s41467-018-08123-8

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