Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

Efficient and site-specific chemical modification of proteins under physiological conditions remains a challenge. Here we report that 1,4-dinitroimidazoles are highly efficient bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. Under acidic to neutral aq...

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Detalles Bibliográficos
Autores principales: Luo, Qunfeng, Tao, Youqi, Sheng, Wangjian, Lu, Jingxia, Wang, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329768/
https://www.ncbi.nlm.nih.gov/pubmed/30635561
http://dx.doi.org/10.1038/s41467-018-08010-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329768/
https://www.ncbi.nlm.nih.gov/pubmed/30635561
http://dx.doi.org/10.1038/s41467-018-08010-2

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