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Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
Efficient and site-specific chemical modification of proteins under physiological conditions remains a challenge. Here we report that 1,4-dinitroimidazoles are highly efficient bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. Under acidic to neutral aq...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329768/ https://www.ncbi.nlm.nih.gov/pubmed/30635561 http://dx.doi.org/10.1038/s41467-018-08010-2 |