Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in females. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results i...

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Detalles Bibliográficos
Autores principales: Herber, Candice B., Krause, William C., Wang, Liping, Bayrer, James R., Li, Alfred, Schmitz, Matthew, Fields, Aaron, Ford, Breanna, Zhang, Zhi, Reid, Michelle S., Nomura, Daniel K., Nissenson, Robert A., Correa, Stephanie M., Ingraham, Holly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329772/
https://www.ncbi.nlm.nih.gov/pubmed/30635563
http://dx.doi.org/10.1038/s41467-018-08046-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329772/
https://www.ncbi.nlm.nih.gov/pubmed/30635563
http://dx.doi.org/10.1038/s41467-018-08046-4

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