Cargando…

Identification and Functional Characterization of a New Splicing Variant of EZH2 in the Central Nervous System

EZH2 plays vital roles in epigenetic regulation, neuronal development and cancer progression. Here a novel EZH2 variant, namely EZH2-X9 (X9 for short) resulting from alternative splicing, was isolated, identified and functionally characterized. X9 was highly expressed in the brains of SD rats, indic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Danyang, Wang, Hui-Li, Huang, Xiyao, Gu, Xiaozhen, Xue, Weizhen, Xu, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329929/ https://www.ncbi.nlm.nih.gov/pubmed/30662348 http://dx.doi.org/10.7150/ijbs.28129

Ejemplares similares

Multiple regulatory aspects of histone methyltransferase EZH2 in Pb-induced neurotoxicity
por: Xue, Wei-Zhen, et al.
Publicado: (2017)

Identification and Characterization of a New Splicing Variant of Prokineticin 2
por: Lattanzi, Roberta, et al.
Publicado: (2022)

Regulatory roles of alternative splicing at Ezh2 gene in mouse oocytes
por: Guo, Shi-meng, et al.
Publicado: (2022)

Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment
por: Gu, Xiaozhen, et al.
Publicado: (2019)

Identification and characterization of naturally occurring splice variants of SAMHD1
por: Welbourn, Sarah, et al.
Publicado: (2012)

Functional coordination of alternative splicing in the mammalian central nervous system
por: Fagnani, Matthew, et al.
Publicado: (2007)

Functional characterization and identification of mouse Rad51d splice variants
por: Gruver, Aaron M, et al.
Publicado: (2009)

Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants
por: van Hoolwerff, Marcella, et al.
Publicado: (2022)

Identification and characterization of novel ETV4 splice variants in prostate cancer
por: Cosi, Irene, et al.
Publicado: (2023)

Identification of a New Splice Variant of the Human ABCC6 Transporter
por: Armentano, Maria Francesca, et al.
Publicado: (2008)

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation
por: Wang, Jun, et al.
Publicado: (2022)

Characterization, treatment and prognosis of retinoblastoma with central nervous system metastasis
por: Hu, Huimin, et al.
Publicado: (2018)

The Calcineurin-Binding, Activity-Dependent Splice Variant Dynamin1xb Is Highly Enriched in Synapses in Various Regions of the Central Nervous System
por: Eich, Marie-Lisa, et al.
Publicado: (2017)

Identification and Characterization of a Splicing Variant in the 5′ UTR of the Human TLR5 Gene
por: Hoang, Thi Xoan, et al.
Publicado: (2017)

Identification and Characterization of Hypothalamic Alternative Splicing Events and Variants in Ovine Fecundity-Related Genes
por: Zhang, Zhuangbiao, et al.
Publicado: (2020)

Identification and characterization of alternative splicing variants of buffalo LXRα expressed in mammary gland
por: Fan, Xinyang, et al.
Publicado: (2022)

Identification and Splicing Characterization of Novel TMC6 and TMC8 Variants Associated With Epidermodysplasia Verruciformis in Three Chinese Families
por: Wang, Rongrong, et al.
Publicado: (2021)

A family of splice variants of CstF-64 expressed in vertebrate nervous systems
por: Shankarling, Ganesh S, et al.
Publicado: (2009)

Identification and Expression Pattern of EZH2 in Pig Developing Fetuses
por: Tan, Baohua, et al.
Publicado: (2020)

The role of EZH1 and EZH2 in development and cancer
por: Lee, Soo Hyun, et al.
Publicado: (2022)

Identification and characterization of seven new exon 11-associated splice variants of the rat mu opioid receptor gene, OPRM1
por: Xu, Jin, et al.
Publicado: (2011)

Splicing Variants of SERPINA1 Gene in Ovine Milk: Characterization of cDNA and Identification of Polymorphisms
por: Marchitelli, Cinzia, et al.
Publicado: (2013)

Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma
por: Yang, Biao, et al.
Publicado: (2022)

Characterization of a new splicing variant of powdery mildew resistance gene Pm4 in synthetic hexaploid wheat YAV249
por: Jin, Yuli, et al.
Publicado: (2022)

In Silico Structural and Functional Characterization of the RSUME Splice Variants
por: Gerez, Juan, et al.
Publicado: (2013)

The identification of protein and RNA interactors of the splicing factor Caper in the adult Drosophila nervous system
por: Titus, M. Brandon, et al.
Publicado: (2023)

Identification of potential functional peptides involved in demyelinating injury in the central nervous system
por: Dong, Xiaohua, et al.
Publicado: (2023)

Identification of splice defects due to noncanonical splice site or deep‐intronic variants in ABCA4
por: Fadaie, Zeinab, et al.
Publicado: (2019)

Identification of a New Cyclovirus in Cerebrospinal Fluid of Patients with Acute Central Nervous System Infections
por: Tan, Le Van, et al.
Publicado: (2013)

Identification and molecular characterization of the alternative spliced variants of beta carbonic anhydrase 1 (βCA1) from Arabidopsis thaliana
por: Shen, Jinyu, et al.
Publicado: (2021)

Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth
por: Xie, Jiansheng, et al.
Publicado: (2022)

Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system
por: Li, Zhaoyang, et al.
Publicado: (2013)

New Insights into the Roles of p53 in Central Nervous System Diseases
por: Li, Haili, et al.
Publicado: (2023)

Identification and characterization of bovine regulator of telomere length elongation helicase gene (RTEL): molecular cloning, expression distribution, splice variants and DNA methylation profile
por: Du, Zhuo, et al.
Publicado: (2007)

Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity
por: Stuckey, Jacob I., et al.
Publicado: (2021)

Identification and Characterization of the Alternatively Spliced Nuclear Receptor Coactivator-6 Isoforms
por: Li, Qingtian, et al.
Publicado: (2011)

Computational Characterization of 3′ Splice Variants in the GFAP Isoform Family
por: Boyd, Sarah E., et al.
Publicado: (2012)

Identification and Characterization of Alternative Splicing Variants and Positive Selection Genes Related to Distinct Growth Rates of Antlers Using Comparative Transcriptome Sequencing
por: Hu, Pengfei, et al.
Publicado: (2022)

New alternative splicing variants of the ATXN2 transcript
por: Lastres-Becker, Isabel, et al.
Publicado: (2019)

5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors
por: Xiang, Pu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9c420uho5rpppum49o9o1ulorh