Bipolar switching by HCN voltage sensor underlies hyperpolarization activation

Despite sharing a common architecture with archetypal voltage-gated ion channels (VGICs), hyperpolarization- and cAMP-activated ion (HCN) channels open upon hyperpolarization rather than depolarization. The basic motions of the voltage sensor and pore gates are conserved, implying that these domains...

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Detalles Bibliográficos
Autores principales: Cowgill, John, Klenchin, Vadim A., Alvarez-Baron, Claudia, Tewari, Debanjan, Blair, Alexander, Chanda, Baron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329955/
https://www.ncbi.nlm.nih.gov/pubmed/30587580
http://dx.doi.org/10.1073/pnas.1816724116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329955/
https://www.ncbi.nlm.nih.gov/pubmed/30587580
http://dx.doi.org/10.1073/pnas.1816724116

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