Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Aberrant fucosylation in cancer cells is considered as a signature of malignant cell transformation and it is associated with tumor progression, metastasis and resistance to chemotherapy. Specifically, in colorectal cancer cells, increased levels of the fucosylated Lewis(x) antigen are attributed to...

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Detalles Bibliográficos
Autores principales: Blanas, Athanasios, Cornelissen, Lenneke A M, Kotsias, Maximilianos, van der Horst, Joost C, van de Vrugt, Henri J, Kalay, Hakan, Spencer, Daniel I R, Kozak, Rad P, van Vliet, Sandra J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Regular Manuscripts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330019/
https://www.ncbi.nlm.nih.gov/pubmed/30476078
http://dx.doi.org/10.1093/glycob/cwy096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330019/
https://www.ncbi.nlm.nih.gov/pubmed/30476078
http://dx.doi.org/10.1093/glycob/cwy096

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