Cargando…

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Aberrant fucosylation in cancer cells is considered as a signature of malignant cell transformation and it is associated with tumor progression, metastasis and resistance to chemotherapy. Specifically, in colorectal cancer cells, increased levels of the fucosylated Lewis(x) antigen are attributed to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blanas, Athanasios, Cornelissen, Lenneke A M, Kotsias, Maximilianos, van der Horst, Joost C, van de Vrugt, Henri J, Kalay, Hakan, Spencer, Daniel I R, Kozak, Rad P, van Vliet, Sandra J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Regular Manuscripts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330019/ https://www.ncbi.nlm.nih.gov/pubmed/30476078 http://dx.doi.org/10.1093/glycob/cwy096

Ejemplares similares

Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis
por: Kotsias, Maximilianos, et al.
Publicado: (2019)

AtFUT4 and AtFUT6 Are Arabinofuranose-Specific Fucosyltransferases
por: Soto, Maria J., et al.
Publicado: (2021)

FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer
por: Bastian, Kayla, et al.
Publicado: (2021)

FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State
por: Blanas, Athanasios, et al.
Publicado: (2020)

Effects of MicroRNAs on Fucosyltransferase 8 (FUT8) Expression in Hepatocarcinoma Cells
por: Bernardi, Cinzia, et al.
Publicado: (2013)

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response
por: Kyunai, Yuki M., et al.
Publicado: (2023)

The α1,6-Fucosyltransferase Gene (fut8) from the Sf9 Lepidopteran Insect Cell Line: Insights into fut8 Evolution
por: Juliant, Sylvie, et al.
Publicado: (2014)

Expression of Fucosyltransferase 4 (FUT4) mRNA Is Increased in Endometrium from Women with Endometriosis
por: Żeberkiewicz, Marta, et al.
Publicado: (2022)

Correction: The α1,6-Fucosyltransferase Gene (fut8) from the Sf9 Lepidopteran Insect Cell Line: Insights into fut8 Evolution
Publicado: (2015)

The stem region of α1,6-fucosyltransferase FUT8 is required for multimer formation but not catalytic activity
por: Tomida, Seita, et al.
Publicado: (2022)

Characterisation of FUT4 and FUT6 α-(1→2)-Fucosyltransferases Reveals that Absence of Root Arabinogalactan Fucosylation Increases Arabidopsis Root Growth Salt Sensitivity
por: Tryfona, Theodora, et al.
Publicado: (2014)

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis
por: Cornelissen, Lenneke A.M., et al.
Publicado: (2019)

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer
por: Cornelissen, Lenneke A. M., et al.
Publicado: (2020)

A gene therapy for inherited blindness using dCas9-VPR–mediated transcriptional activation
por: Böhm, Sybille, et al.
Publicado: (2020)

Expression of the gene encoding secretor type galactoside 2 α fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions
por: Campi, Carlos, et al.
Publicado: (2012)

Beyond antibody fucosylation: α-(1,6)-fucosyltransferase (Fut8) as a potential new therapeutic target for cancer immunotherapy
por: Mao, Changchuin, et al.
Publicado: (2023)

Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis
por: Kotsias, Maximilianos, et al.
Publicado: (2019)

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling
por: Lin, Shanyi, et al.
Publicado: (2021)

Up-Regulating ERIC by CRISPR-dCas9-VPR Inhibits Cell Proliferation and Invasion and Promotes Apoptosis in Human Bladder Cancer
por: Yang, Jiangeng, et al.
Publicado: (2021)

A novel fungal gene regulation system based on inducible VPR-dCas9 and nucleosome map-guided sgRNA positioning
por: Schüller, Andreas, et al.
Publicado: (2020)

Different Effects of Androgen on the Expression of Fut1, Fut2, Fut4 and Fut9 in Male Mouse Reproductive Tract
por: Wang, Chun-Mei, et al.
Publicado: (2013)

Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery
por: Pakalniškytė, Dalia, et al.
Publicado: (2022)

A Bitter Sweet Symphony: Immune Responses to Altered O-glycan Epitopes in Cancer
por: Cornelissen, Lenneke A.M., et al.
Publicado: (2016)

Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0
por: Teylaert, Béatrice, et al.
Publicado: (2011)

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy
por: Blanas, Athanasios, et al.
Publicado: (2018)

Corrigendum: Fucosylated Antigens in Cancer: An Alliance Toward Tumor Progression, Metastasis, and Resistance to Chemotherapy
por: Blanas, Athanasios, et al.
Publicado: (2018)

Glycomic Expression in Esophageal Disease
por: Mohanty, Sanjay, et al.
Publicado: (2012)

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS
por: Kotsias, Maximilianos, et al.
Publicado: (2021)

Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1
por: Polanco, Gloria, et al.
Publicado: (2022)

Vpr makes holes
por: Wells, William A.
Publicado: (2001)

Vpr Is a VIP: HIV Vpr and Infected Macrophages Promote Viral Pathogenesis
por: Lubow, Jay, et al.
Publicado: (2020)

Futs and the Higgs-boson
por: Heinemeyer, Sven, et al.
Publicado: (2012)

Characterization of bovine FUT7 furthers understanding of FUT7 evolution in mammals
por: Laporte, Benoît, et al.
Publicado: (2012)

Variation of Human Salivary O-Glycome
por: Kozak, Radoslaw P., et al.
Publicado: (2016)

Functional characterization of Schistosoma mansoni fucosyltransferases in Nicotiana benthamiana plants
por: van Noort, Kim, et al.
Publicado: (2020)

Vpr loosens chromatid ties
por: Short, Ben
Publicado: (2011)

Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages
por: Jacquot, Guillaume, et al.
Publicado: (2007)

Shotgun Glycomics: A Microarray Strategy for Functional Glycomics
por: Song, Xuezheng, et al.
Publicado: (2010)

Comparing the Immunoexpression of FUT3 and FUT6 between Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia
por: de Albuquerque Vasconcelos, Juliana Lúcia, et al.
Publicado: (2013)

Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China
por: Hu, Dingyuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dk1f3g806288gvqqf7eb7q4bue