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High resolution genetic mapping of putative causal interactions between regions of open chromatin

Physical interaction of regulatory elements in three-dimensional space poses a challenge for studies of disease because noncoding risk variants may be substantial distances from the genes they regulate. Experimental methods to capture these interactions, such as chromosome conformation capture (3C),...

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Detalles Bibliográficos
Autores principales: Kumasaka, Natsuhiko, Knights, Andrew, Gaffney, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330062/
https://www.ncbi.nlm.nih.gov/pubmed/30478436
http://dx.doi.org/10.1038/s41588-018-0278-6