Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

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Detalles Bibliográficos
Autores principales: Karaś, Kaja, Sałkowska, Anna, Sobalska-Kwapis, Marta, Walczak-Drzewiecka, Aurelia, Strapagiel, Dominik, Dastych, Jarosław, Bachorz, Rafał A., Ratajewski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330298/
https://www.ncbi.nlm.nih.gov/pubmed/30666196
http://dx.doi.org/10.3389/fphar.2018.01460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330298/
https://www.ncbi.nlm.nih.gov/pubmed/30666196
http://dx.doi.org/10.3389/fphar.2018.01460

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