Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties

We present an approach to assess antibody CDR-H3 loops according to their dynamic properties using molecular dynamics simulations. We selected six antibodies in three pairs differing substantially in their individual promiscuity respectively specificity. For two pairs of antibodies crystal structure...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Loeffler, Johannes R., Kraml, Johannes, Kahler, Ursula, Kamenik, Anna S., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330313/
https://www.ncbi.nlm.nih.gov/pubmed/30666252
http://dx.doi.org/10.3389/fimmu.2018.03065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330313/
https://www.ncbi.nlm.nih.gov/pubmed/30666252
http://dx.doi.org/10.3389/fimmu.2018.03065

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