Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Niemann-Pick type C1 (NPC1) disease is caused by a deleterious mutation in the Npc1 gene, causing lysosomal accumulation of unesterified cholesterol and sphingolipids. Consequently, NPC1 disease patients suffer from severe neurovisceral symptoms which, in the absence of effective treatments, result...

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Detalles Bibliográficos
Autores principales: Houben, Tom, Magro dos Reis, Inês, Oligschlaeger, Yvonne, Steinbusch, Hellen, Gijbels, Marion J. J., Hendrikx, Tim, Binder, Christoph J., Cassiman, David, Westerterp, Marit, Prickaerts, Jos, Shiri-Sverdlov, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330339/
https://www.ncbi.nlm.nih.gov/pubmed/30666257
http://dx.doi.org/10.3389/fimmu.2018.03089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330339/
https://www.ncbi.nlm.nih.gov/pubmed/30666257
http://dx.doi.org/10.3389/fimmu.2018.03089

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