A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

Excitatory neurons are preferentially impaired in early Alzheimer’s disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to inhibitory neurons, not only...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Hongjun, Possenti, Andrea, Freer, Rosie, Nakano, Yoshikazu, Hernandez Villegas, Nancy C., Tang, Maoping, Cauhy, Paula V. M, Lassus, Benjamin A., Chen, Shuo, Fowler, Stephanie L., Figueroa, Helen Y., Huey, Edward D., Johnson, Gail V.W., Vendruscolo, Michele, Duff, Karen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330709/
https://www.ncbi.nlm.nih.gov/pubmed/30559469
http://dx.doi.org/10.1038/s41593-018-0298-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330709/
https://www.ncbi.nlm.nih.gov/pubmed/30559469
http://dx.doi.org/10.1038/s41593-018-0298-7

Ejemplares similares