Cargando…

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

BACKGROUND: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. METHODS: Using a novel enzyme-linked i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yokoyama, Yayoi, Ito, Takashi, Yasuda, Tomotsugu, Furubeppu, Hiroaki, Kamikokuryo, Chinatsu, Yamada, Shingo, Maruyama, Ikuro, Kakihana, Yasuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330748/ https://www.ncbi.nlm.nih.gov/pubmed/30651722 http://dx.doi.org/10.1186/s12959-018-0190-4

Ejemplares similares

Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study
por: Ito, Takashi, et al.
Publicado: (2019)

Differential Regulation of Damage-Associated Molecular Pattern Release in a Mouse Model of Skeletal Muscle Ischemia/Reperfusion Injury
por: Furubeppu, Hiroaki, et al.
Publicado: (2021)

Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin
por: Arishima, Takuro, et al.
Publicado: (2018)

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3
por: Ito, Takashi, et al.
Publicado: (2018)

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care
por: Hatanaka, Kosaku, et al.
Publicado: (2021)

Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury
por: Shimono, Kenshin, et al.
Publicado: (2023)

Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice
por: Madokoro, Yutaro, et al.
Publicado: (2022)

Fulminant myocarditis associated with severe fever with thrombocytopenia syndrome: a case report
por: Miyamoto, Shotaro, et al.
Publicado: (2019)

An evaluation of circulating activated TAFI in septic DIC: a case series and review of the literature
por: Totoki, Takaaki, et al.
Publicado: (2022)

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism
por: Nakahara, Mayumi, et al.
Publicado: (2013)

A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia
por: Atari, Bengo, et al.
Publicado: (2020)

Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit
por: Yashima, Nozomi, et al.
Publicado: (2020)

Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus
por: Ito, Takashi, et al.
Publicado: (2020)

Sepsis-induced myocardial dysfunction: pathophysiology and management
por: Kakihana, Yasuyuki, et al.
Publicado: (2016)

Comparison of the levels of neopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-2
por: Hara, Satoshi, et al.
Publicado: (2022)

Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation
por: Ito, Takashi, et al.
Publicado: (2021)

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
por: Shaw, Rebecca J., et al.
Publicado: (2021)

Microcirculation and intravascular coagulopathy in patients with severe sepsis and septic shock
por: Wimmer, R, et al.
Publicado: (2010)

Management Strategies in Septic Coagulopathy: A Review of the Current Literature
por: Czempik, Piotr F., et al.
Publicado: (2023)

Specific detection of high mobility group box 1 degradation product with a novel ELISA
por: Totoki, Takaaki, et al.
Publicado: (2021)

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
por: Shrestha, Binita, et al.
Publicado: (2019)

Effects of Neutrophil Extracellular Traps in Patients With Septic Coagulopathy and Their Interaction With Autophagy
por: Mao, Jia-Yu, et al.
Publicado: (2021)

Acute Traumatic Coagulopathy: The Value of Histone in Pediatric Trauma Patients
por: Ulusoy, Emel, et al.
Publicado: (2018)

Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?
por: Ligi, Daniela, et al.
Publicado: (2022)

Head-to-head comparison of cytokines storm-coagulopathy in septic shock and COVID-19
por: De Poortere, J., et al.
Publicado: (2021)

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study
por: Iwasaki, Yudai, et al.
Publicado: (2023)

Uric acid enhances alteplase-mediated thrombolysis as an antioxidant
por: Kikuchi, Kiyoshi, et al.
Publicado: (2018)

Cytokine storm induced coagulopathy in septic shock and critical Covid-19: head-to-head comparison
por: Dechamps, M D M, et al.
Publicado: (2021)

HMGB1 Promotes the Development of Pulmonary Arterial Hypertension in Rats
por: Sadamura-Takenaka, Yukari, et al.
Publicado: (2014)

Septic Shock, Adult Respiratory Distress Syndrome, and Disseminated Intravascular Coagulopathy Following Midtrimester Genetic Amniocentesis
por: Johnson, J. R., et al.
Publicado: (1997)

Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients
por: García-Giménez, José Luis, et al.
Publicado: (2023)

Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview
por: Kushimoto, Shigeki, et al.
Publicado: (2017)

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats
por: Helms, Julie, et al.
Publicado: (2017)

Anticoagulant therapy for septic coagulopathy and disseminated intravascular coagulation: where do KyberSept and SCARLET leave us?
por: Wiedermann, Christian J.
Publicado: (2020)

Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study
por: Dechamps, Mélanie, et al.
Publicado: (2022)

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
por: Sharma, Sriganesh B., et al.
Publicado: (2023)

Hypothermic circulatory arrest does not induce coagulopathy in vitro
por: Ise, Hayato, et al.
Publicado: (2022)

Prevalence and Characteristics of Hepatic Hemangioma Associated with Coagulopathy and Its Predictive Risk Factors
por: Maruyama, Shigeo, et al.
Publicado: (2022)

Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients
por: Prado, Yolanda, et al.
Publicado: (2023)

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma
por: Johansson, Pär I, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_n5barfatm72d4dk69msd6udcgl