PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation

Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage cancers, often show signs of a telomere crisi...

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Detalles Bibliográficos
Autores principales: Ngo, Greg, Hyatt, Sam, Grimstead, Julia, Jones, Rhiannon, Hendrickson, Eric, Pepper, Chris, Baird, Duncan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331021/
https://www.ncbi.nlm.nih.gov/pubmed/30680069
http://dx.doi.org/10.18632/oncotarget.26499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331021/
https://www.ncbi.nlm.nih.gov/pubmed/30680069
http://dx.doi.org/10.18632/oncotarget.26499

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