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PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation
Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage cancers, often show signs of a telomere crisi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331021/ https://www.ncbi.nlm.nih.gov/pubmed/30680069 http://dx.doi.org/10.18632/oncotarget.26499 |