Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3β-mediated c-FLIP(L) degradation in non-small cell lung cancer

BACKGROUND: Metformin, a first-line antidiabetic drug, has recently been reported with anticancer activities in various cancers; however, the underlying mechanisms remain elusive. The aim of the present study was to investigate the role of cellular FADD-like IL-1β-converting enzyme (FLICE)-inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Zhuang, Zhu, Tingting, Luo, Wei, Lv, Yuanyuan, Zhang, Liyan, Wang, Chu, Li, Min, Wu, Wenjuan, Shi, Shaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331071/
https://www.ncbi.nlm.nih.gov/pubmed/30666163
http://dx.doi.org/10.2147/CMAR.S178688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331071/
https://www.ncbi.nlm.nih.gov/pubmed/30666163
http://dx.doi.org/10.2147/CMAR.S178688

Ejemplares similares