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Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3β-mediated c-FLIP(L) degradation in non-small cell lung cancer

BACKGROUND: Metformin, a first-line antidiabetic drug, has recently been reported with anticancer activities in various cancers; however, the underlying mechanisms remain elusive. The aim of the present study was to investigate the role of cellular FADD-like IL-1β-converting enzyme (FLICE)-inhibitor...

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Detalles Bibliográficos
Autores principales:	Luo, Zhuang, Zhu, Tingting, Luo, Wei, Lv, Yuanyuan, Zhang, Liyan, Wang, Chu, Li, Min, Wu, Wenjuan, Shi, Shaoqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331071/ https://www.ncbi.nlm.nih.gov/pubmed/30666163 http://dx.doi.org/10.2147/CMAR.S178688

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