Determination of blood dexmedetomidine in dried blood spots by LC-MS/MS to screen therapeutic levels in paediatric patients

Dexmedetomidine is an imidazole derivative, with high affinity for α2 adrenergic receptors, used for sedation, analgesia and adjuvant anaesthesia. In this study, an analytical method for the quantification of dexmedetomidine in dried blood spots was developed, validated and applied. The drug was ext...

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Detalles Bibliográficos
Autores principales: Rivera-Espinosa, Liliana, Toledo-López, Alejandra, Chávez-Pacheco, Juan Luis, Alemón-Medina, Radamés, Gómez-Garduño, Josefina, Lugo-Goytia, Gustavo, García-Álvarez, Raquel, Juárez-Olguín, Hugo, Torres-Espíndola, Luz María, Pérez-Guillé, María-Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331108/
https://www.ncbi.nlm.nih.gov/pubmed/30640937
http://dx.doi.org/10.1371/journal.pone.0210391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331108/
https://www.ncbi.nlm.nih.gov/pubmed/30640937
http://dx.doi.org/10.1371/journal.pone.0210391

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