Cargando…

Determination of blood dexmedetomidine in dried blood spots by LC-MS/MS to screen therapeutic levels in paediatric patients

Dexmedetomidine is an imidazole derivative, with high affinity for α2 adrenergic receptors, used for sedation, analgesia and adjuvant anaesthesia. In this study, an analytical method for the quantification of dexmedetomidine in dried blood spots was developed, validated and applied. The drug was ext...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rivera-Espinosa, Liliana, Toledo-López, Alejandra, Chávez-Pacheco, Juan Luis, Alemón-Medina, Radamés, Gómez-Garduño, Josefina, Lugo-Goytia, Gustavo, García-Álvarez, Raquel, Juárez-Olguín, Hugo, Torres-Espíndola, Luz María, Pérez-Guillé, María-Gabriela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331108/ https://www.ncbi.nlm.nih.gov/pubmed/30640937 http://dx.doi.org/10.1371/journal.pone.0210391

Ejemplares similares

Population Pharmacokinetics and Pharmacodynamics of Dexmedetomidine in Children Undergoing Ambulatory Surgery
por: Pérez-Guillé, María-Gabriela, et al.
Publicado: (2018)

A New Method to Quantify Ifosfamide Blood Levels Using Dried Blood Spots and UPLC-MS/MS in Paediatric Patients with Embryonic Solid Tumours
por: Torres, Luz-María, et al.
Publicado: (2015)

Comparative Bioavailability and Pharmacokinetics Between the Solid Form of Metformin vs a Novel Liquid Extemporaneous Formulation in Children
por: Alemón-Medina, Radamés, et al.
Publicado: (2021)

A selective detection of lysophosphatidylcholine in dried blood spots for diagnosis of adrenoleukodystrophy by LC-MS/MS
por: Mashima, Ryuichi, et al.
Publicado: (2016)

Dried Plasma Spot Based LC–MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients
por: Cao, Haiwei, et al.
Publicado: (2022)

LC-MS/MS-based enzyme assay for lysosomal acid lipase using dried blood spots
por: Ohira, Mari, et al.
Publicado: (2022)

LC-MS/MS for Ultra-Sensitive Quantification of Multiple Estrogens in the Blood and Brain
por: Jalabert, Cecilia, et al.
Publicado: (2021)

Ultrasensitive Quantification of Multiple Estrogens in Songbird Blood and Microdissected Brain by LC-MS/MS
por: Jalabert, Cecilia, et al.
Publicado: (2022)

Development of dried blood spot quality control materials for adenosine deaminase severe combined immunodeficiency and an LC-MS/MS method for their characterization
por: Young, Brian, et al.
Publicado: (2020)

Sensitive and Robust LC-MS/MS Assay to Quantify 25-Hydroxyvitamin D in Leftover Protein Extract from Dried Blood Spots
por: Boelt, Sanne Grundvad, et al.
Publicado: (2021)

RF15 | PMON304 Utilizing LC-MS/MS for the clinical quantitation of testosterone using dried blood spot and how it compare to serum
por: Hauck, Zane Z, et al.
Publicado: (2022)

An LC–MS/MS-Based Method for the Quantification of Pyridox(am)ine 5′-Phosphate Oxidase Activity in Dried Blood Spots from Patients with Epilepsy
por: Wilson, Matthew P., et al.
Publicado: (2017)

Development and Validation of a Simple and Sensitive LC-MS/MS Method for Quantification of Metformin in Dried Blood Spot Its Application as an Indicator for Medication Adherence
por: ALquadeib, Bushra T, et al.
Publicado: (2021)

Simultaneous LC–MS/MS method for the quantitation of Azithromycin, Hydroxychloroquine and its metabolites in SARS-CoV-2(−/ +) populations using dried blood spots
por: Chhonker, Yashpal S., et al.
Publicado: (2023)

Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice
por: Rmandić, Milena, et al.
Publicado: (2022)

Identification and quantification of mepirapim and acetyl fentanyl in authentic human whole blood and urine samples by GC–MS/MS and LC–MS/MS
por: Mochizuki, Akira, et al.
Publicado: (2017)

Detection of BPDE-DNA adducts in human umbilical cord blood by LC-MS/MS analysis
por: Guo, Ling, et al.
Publicado: (2019)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Simultaneous Determination of Cyclosporine A, Tacrolimus, Sirolimus, and Everolimus in Whole-Blood Samples by LC-MS/MS
por: Karapirli, Mustafa, et al.
Publicado: (2012)

Comparison of LC-MS/MS and EMIT methods for the precise determination of blood sirolimus in children with vascular anomalies
por: Zhao, Yue-Tao, et al.
Publicado: (2022)

LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study
por: Cui, Wenjuan, et al.
Publicado: (2018)

Development, validation and clinical application of a method for the simultaneous quantification of lamivudine, emtricitabine and tenofovir in dried blood and dried breast milk spots using LC–MS/MS
por: Waitt, Catriona, et al.
Publicado: (2017)

Fecal metabolite analysis of Japanese macaques in Yakushima by LC-MS/MS and LC-QTOF-MS
por: TSUCHIDA, Sayaka, et al.
Publicado: (2021)

LC–MS-Based Direct Quantification of MicroRNAs in Rat Blood
por: Cho, Hyun-Deok, et al.
Publicado: (2023)

Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate—a validated assay for the clinic
por: Hooff, Gero P., et al.
Publicado: (2011)

Dynamic and temporal assessment of human dried blood spot MS/MS(ALL) shotgun lipidomics analysis
por: Gao, Fei, et al.
Publicado: (2017)

Development, validation, and clinical application of an FIA‐MS/MS method for the quantification of lysophosphatidylcholines in dried blood spots
por: Yue, Xiaofei, et al.
Publicado: (2021)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Application of LC–MS/MS in the Mycotoxins Studies
por: Gámiz-Gracia, Laura, et al.
Publicado: (2020)

Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
por: Gómez-Garduño, Josefina, et al.
Publicado: (2022)

Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach
por: Dubland, Joshua A., et al.
Publicado: (2021)

LC-MS/MS Method for the Quantification of PARP Inhibitors Olaparib, Rucaparib and Niraparib in Human Plasma and Dried Blood Spot: Development, Validation and Clinical Validation for Therapeutic Drug Monitoring
por: Canil, Giovanni, et al.
Publicado: (2023)

High sensitivity methods to quantify chloroquine and its metabolite in human blood samples using LC–MS/MS
por: Kaewkhao, Karnrawee, et al.
Publicado: (2019)

Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption
por: Mandrioli, Roberto, et al.
Publicado: (2020)

Development and validation of an LC-MS/MS method for determination of B vitamins and some its derivatives in whole blood
por: Kahoun, David, et al.
Publicado: (2022)

A Novel LC–MS/MS-Based Method for the Diagnosis of ADA2 Deficiency from Dried Plasma Spot
por: Cafaro, Alessia, et al.
Publicado: (2021)

Automated LC-MS/MS: Ready for the clinical routine Laboratory?
por: Junger, Sina, et al.
Publicado: (2023)

Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A
por: Zhang, Kai
Publicado: (2021)

Co-Occurrence of Hypoglycin A and Hypoglycin B in Sycamore and Box Elder Maple Proved by LC-MS/MS and LC-HR-MS
por: El-Khatib, Ahmed H., et al.
Publicado: (2022)

Development and Validation of an LC-MS/MS Method and Comparison with a GC-MS Method to Measure Phenytoin in Human Brain Dialysate, Blood, and Saliva
por: Hösli, Raphael, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6p1sh67peubogjnurs1b4t2vrc