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Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot
Through the application of a region-focused saturation mutagenesis and randomization approach, protein engineering of the Cal-A enzyme was undertaken with the goal of conferring new triglyceride selectivity. Little is known about the mode of triglyceride binding to Cal-A. Engineering Cal-A thus requ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331120/ https://www.ncbi.nlm.nih.gov/pubmed/30640952 http://dx.doi.org/10.1371/journal.pone.0210100 |