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Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling

BACKGROUND: There are few clinical challenges associated with the treatment of colorectal cancer (CRC). Studies have shown that TGF-β plays a crucial role in CRC. Importantly, celastrol, a major components of the root extract of the traditional Chinese herb Tripterygium wilfordii Hook F, has been sh...

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Detalles Bibliográficos
Autores principales: Jiang, Zhitao, Cao, Qianyu, Dai, Guoliang, Wang, Jianchun, Liu, Chundi, Lv, Lingyan, Pan, Jinhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331187/
https://www.ncbi.nlm.nih.gov/pubmed/30666129
http://dx.doi.org/10.2147/OTT.S187817