Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

Type 2 diabetes (T2D) develops after years of prediabetes during which high glucose (glucotoxicity) impairs insulin secretion. We report that the ATP-conducting mitochondrial outer membrane voltage-dependent anion channel-1 (VDAC1) is upregulated in islets from T2D and non-diabetic organ donors unde...

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Detalles Bibliográficos
Autores principales: Zhang, Enming, Mohammed Al-Amily, Israa, Mohammed, Sarheed, Luan, Cheng, Asplund, Olof, Ahmed, Meftun, Ye, Yingying, Ben-Hail, Danya, Soni, Arvind, Vishnu, Neelanjan, Bompada, Pradeep, De Marinis, Yang, Groop, Leif, Shoshan-Barmatz, Varda, Renström, Erik, Wollheim, Claes B., Salehi, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331340/
https://www.ncbi.nlm.nih.gov/pubmed/30293774
http://dx.doi.org/10.1016/j.cmet.2018.09.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331340/
https://www.ncbi.nlm.nih.gov/pubmed/30293774
http://dx.doi.org/10.1016/j.cmet.2018.09.008

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