PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic, metabolomic, and bioergenetic analyses, we identify two molecular subgroups, low- and high-OXPHOS. While low-OXPHOS exhibit a glyco...

Descripción completa

Detalles Bibliográficos
Autores principales: Gentric, Géraldine, Kieffer, Yann, Mieulet, Virginie, Goundiam, Oumou, Bonneau, Claire, Nemati, Fariba, Hurbain, Ilse, Raposo, Graca, Popova, Tatiana, Stern, Marc-Henri, Lallemand-Breitenbach, Valérie, Müller, Sebastian, Cañeque, Tatiana, Rodriguez, Raphaël, Vincent-Salomon, Anne, de Thé, Hugues, Rossignol, Rodrigue, Mechta-Grigoriou, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331342/
https://www.ncbi.nlm.nih.gov/pubmed/30244973
http://dx.doi.org/10.1016/j.cmet.2018.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331342/
https://www.ncbi.nlm.nih.gov/pubmed/30244973
http://dx.doi.org/10.1016/j.cmet.2018.09.002

Ejemplares similares