Deducing Mucosal Pharmacokinetics and Pharmacodynamics of the Anti-HIV Molecule Tenofovir from Measurements in Blood

Microbicide pharmacokinetic (PK) studies typically sample drug in luminal fluid, mucosal tissue, and blood. Blood measurements can be conducted most frequently, serially within subjects. Antiretroviral drugs, however, act against HIV in mucosal tissue/cells. We computationally modeled the extent mea...

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Detalles Bibliográficos
Autores principales: Govil, Sachin, Katz, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331591/
https://www.ncbi.nlm.nih.gov/pubmed/30643165
http://dx.doi.org/10.1038/s41598-018-36004-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331591/
https://www.ncbi.nlm.nih.gov/pubmed/30643165
http://dx.doi.org/10.1038/s41598-018-36004-z

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