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Aminoacyl sulfonamide assembly in SB-203208 biosynthesis

Sulfonamide is present in many important drugs, due to its unique chemical and biological properties. In contrast, naturally occurring sulfonamides are rare, and their biosynthetic knowledge are scarce. Here we identify the biosynthetic gene cluster of sulfonamide antibiotics, altemicidin, SB-203207...

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Detalles Bibliográficos
Autores principales: Hu, Zhijuan, Awakawa, Takayoshi, Ma, Zhongjun, Abe, Ikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331615/
https://www.ncbi.nlm.nih.gov/pubmed/30643149
http://dx.doi.org/10.1038/s41467-018-08093-x